Dasatinib (hydrochloride)

MedChem Express

Dasatinib (hydrochloride) [854001-07-3]

10

854001-07-3

Research Use Only

99.67

C22H27Cl2N7O2S

524.47

Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The K i s are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC 50 s of [1] . Dasatinib hydrochloride also induces apoptosis and autophagy .

O=C(C1=CN=C(S1)NC2=NC(C)=NC(N3CCN(CC3)CCO)=C2)NC4=C(C=CC=C4Cl)C.[H]Cl

2°C to 8°C

12352200