DCLK3 antibody

GeneTex

DCLK3 antibody

9

WB: 1 - 2 microg/mL. IHC-P: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

DCLK3

doublecortin like kinase 3

CLICK-I,II-related; CLR; DCAMKL3; DCDC3C; DCK3; doublecortin and CaM kinase-like 3; doublecortin domain-containing protein 3C; doublecortin-like and CAM kinase-like 3; serine/threonine-protein kinase DCLK3

Rabbit

IgG

Serine/threonine-protein kinase DCLK3

DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization.

-20°C or -80°C,2°C to 8°C

12352203