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ProductsBack/Decitabine [2353-33-5]
Chemical Structure
Chemical Structure
Chemical Structure

Decitabine [2353-33-5]

Research Use Only
CDX-A0563
Chemodex
CAS Number2353-33-5
DownloadDatasheet
Product group Chemicals
Estimated Purity>99%
Molecular Weight228.21
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Overview

  • Supplier
    Chemodex
  • Product Name
    Decitabine [2353-33-5]
  • Delivery Days Customer
    10
  • CAS Number
    2353-33-5
  • Certification
    Research Use Only
  • Estimated Purity
    >99%
  • Hazard Information
    Danger
  • Molecular Formula
    C8H12N4O4
  • Molecular Weight
    228.21
  • Scientific Description
    Chemical. CAS: 2353-33-5. Formula: C8H12N4O4. MW: 228.21. Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling opening chromatin. This cytosine analog incorporates into DNA, inhibit DNA methyltransferases, and cause hypomethylation of cytosine residues in the absence of any significant mutagenic effects. Decitabine is a potent antileukaemic agent with activity in the treatment of haematological malignancies such as acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML) and myelodysplastic syndrome (preleukaemia) and has been suggested to reverse chemotherapy resistance in several cancer types. It is used as a chemotherapeutic agent, suppresses growth of human tumor cell lines, shown to reverse embryonic stem cell differentiation and prevent atherosclerosis lesion formation and reduces the production of inflammatory cytokines by macrophages. - Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling opening chromatin. This cytosine analog incorporates into DNA, inhibit DNA methyltransferases, and cause hypomethylation of cytosine residues in the absence of any significant mutagenic effects. Decitabine is a potent antileukaemic agent with activity in the treatment of haematological malignancies such as acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML) and myelodysplastic syndrome (preleukaemia) and has been suggested to reverse chemotherapy resistance in several cancer types. It is used as a chemotherapeutic agent, suppresses growth of human tumor cell lines, shown to reverse embryonic stem cell differentiation and prevent atherosclerosis lesion formation and reduces the production of inflammatory cytokines by macrophages.
  • SMILES
    O[C@H]1C[C@H](N2C(N=C(N)N=C2)=O)O[C@@H]1CO
  • Storage Instruction
    -20°C,2°C to 8°C,RT
  • UNSPSC
    12352200