Western Blot Positive WB detected in: 293 whole cell lysate All lanes: DKK1 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 29 kDa Observed band size: 38 kDa
Western Blot Positive WB detected in: 293 whole cell lysate All lanes: DKK1 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 29 kDa Observed band size: 38 kDa
DKK1 Recombinant Monoclonal Antibody
CSB-RA576260A0HU
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetDKK1
Overview
- SupplierCusabio
- Product NameDKK1 Recombinant Monoclonal Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID1D12
- ConjugateUnconjugated
- Gene ID22943
- Target nameDKK1
- Target descriptiondickkopf WNT signaling pathway inhibitor 1
- Target synonymsdickkopf 1 homolog; dickkopf-1 like; dickkopf-like protein 1; dickkopf-related protein 1; DKK-1; SK
- IsotypeIgG
- Protein IDO94907
- Protein NameDickkopf-related protein 1
- Scientific DescriptionAntagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203