DLL4 (human):Fc (human) (rec.)

AdipoGen Life Sciences

DLL4 (human):Fc (human) (rec.)

10

Research Use Only

>95%

DLL4

delta like canonical Notch ligand 4

AOS6, delta4, hdelta2, delta-like protein 4, delta 4, delta ligand 4, delta-like 4 homolog, delta-like 4 protein, drosophila Delta homolog 4, notch ligand DLL4, notch ligand delta-2

Delta-like protein 4

Protein. Signal peptide and extracellular domain of human DLL4 (aa 1-529) are fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: 95% (SDS-PAGE). The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina. - The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.

-20°C,2°C to 8°C

41116100

Human