DLL4 (human):Fc (human) (rec.)
AG-40A-0077Y
Overview
- SupplierAdipoGen Life Sciences
- Product NameDLL4 (human):Fc (human) (rec.)
- Delivery Days Customer10
- Estimated Purity>95%
- Protein IDQ9NR61
- Protein NameDelta-like protein 4
- Scientific DescriptionProtein. Signal peptide and extracellular domain of human DLL4 (aa 1-529) are fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.01EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS + 0.5 % Trehalose. Interacts with human Notch1 (as confirmed by flow cytometry). Purity: >95% (SDS-PAGE). The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina. - The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352202
