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ProductsBack/DNA ligase I antibody [10H5]

DNA ligase I antibody [10H5]

Research Use Only
GTX70141
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetLIG1
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Overview

  • Supplier
    GeneTex
  • Product Name
    DNA ligase I antibody [10H5]
  • Delivery Days Customer
    9
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    10H5
  • Concentration
    0.5 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3978
  • Target name
    LIG1
  • Target description
    DNA ligase 1
  • Target synonyms
    DNA ligase 1; ligase I, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 1
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • Hepatitis B virus cccDNA is formed through distinct repair processes of each strand. Wei L et al., 2021 Mar 11, Nat Commun
    Read more
  • Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation. Wei L et al., 2020 May, Nat Microbiol
    Read more
  • Overexpression of PCNA Attenuates Oxidative Stress-Caused Delay of Gap-Filling during Repair of UV-Induced DNA Damage. Tsai YC et al., 2017, J Nucleic Acids
    Read more
  • Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein. Yuan Y et al., 2015 Dec 2, Nucleic Acids Res
    Read more
  • Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. Horton JK et al., 2013 Sep, DNA Repair (Amst)
    Read more
  • Interaction between DNA Polymerase beta and BRCA1. Masaoka A et al., 2013, PLoS One
    Read more
  • Pol beta associated complex and base excision repair factors in mouse fibroblasts. Prasad R et al., 2012 Dec, Nucleic Acids Res
    Read more
  • DNA polymerase beta-dependent long patch base excision repair in living cells. Asagoshi K et al., 2010 Feb 4, DNA Repair (Amst)
    Read more
  • Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity. Guo Z et al., 2009 Jun, Nucleic Acids Res
    Read more
  • A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes. Song W et al., 2007 Aug 3, J Biol Chem
    Read more