DNA ligase I antibody [10H5]
GTX70141
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetLIG1
Overview
- SupplierGeneTex
- Product NameDNA ligase I antibody [10H5]
- Delivery Days Customer9
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID10H5
- Concentration0.5 mg/ml
- ConjugateUnconjugated
- Gene ID3978
- Target nameLIG1
- Target descriptionDNA ligase 1
- Target synonymsDNA ligase 1; ligase I, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 1
- HostMouse
- IsotypeIgG1
- Protein IDP18858
- Protein NameDNA ligase 1
- Scientific DescriptionThis gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Hepatitis B virus cccDNA is formed through distinct repair processes of each strand. Wei L et al., 2021 Mar 11, Nat CommunRead more
- Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation. Wei L et al., 2020 May, Nat MicrobiolRead more
- Overexpression of PCNA Attenuates Oxidative Stress-Caused Delay of Gap-Filling during Repair of UV-Induced DNA Damage. Tsai YC et al., 2017, J Nucleic AcidsRead more
- Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein. Yuan Y et al., 2015 Dec 2, Nucleic Acids ResRead more
- Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. Horton JK et al., 2013 Sep, DNA Repair (Amst)Read more
- Interaction between DNA Polymerase beta and BRCA1. Masaoka A et al., 2013, PLoS OneRead more
- Pol beta associated complex and base excision repair factors in mouse fibroblasts. Prasad R et al., 2012 Dec, Nucleic Acids ResRead more
- DNA polymerase beta-dependent long patch base excision repair in living cells. Asagoshi K et al., 2010 Feb 4, DNA Repair (Amst)Read more
- Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity. Guo Z et al., 2009 Jun, Nucleic Acids ResRead more
- A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes. Song W et al., 2007 Aug 3, J Biol ChemRead more
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