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DNA-PKcs antibody [18-2]

GTX21832
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPRKDC
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Overview

  • Supplier
    GeneTex
  • Product Name
    DNA-PKcs antibody [18-2]
  • Delivery Days Customer
    9
  • Application Supplier Note
    For FuncS: Inhibits (50%) DNA-dependent Phosphorylation - Use at an assay dependent dilution. For IF: Use at an assay dependent dilution. For IHC-P: Use at a dilution of 1:400. For IP: Native and denatured - Use protein G - Use at a dilution of 1:400. For WB: Use at a dilution of 1:200. Optimal dilutions/concentrations should be determined by the researcher.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    18-2
  • Concentration
    0.2 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5591
  • Target name
    PRKDC
  • Target description
    protein kinase, DNA-activated, catalytic subunit
  • Target synonyms
    DNA-PKC, DNA-PKcs, DNAPK, DNAPKc, DNPK1, HYRC, HYRC1, IMD26, S473K, XRCC7, p350, DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, hyper-radiosensitivity of murine scid mutation, complementing 1, p460, protein kinase, DNA-activated, catalytic polypeptide, ser-473 kinase
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP78527
  • Protein Name
    DNA-dependent protein kinase catalytic subunit
  • Scientific Description
    This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Sato H, Yoneda M, Honma R, et al. Measles Virus Infection Inactivates Cellular Protein Phosphatase 5 with Consequent Suppression of Sp1 and c-Myc Activities. J Virol. 2015,89(19):9709-18. doi: 10.1128/JVI.00825-15
    Read this paper
  • You BJ, Wu YC, Lee CL, et al. Non-homologous end joining pathway is the major route of protection against 4β-hydroxywithanolide E-induced DNA damage in MCF-7 cells. Food Chem Toxicol. 2014,65:205-12. doi: 10.1016/j.fct.2013.12.026
    Read this paper
  • Chiang JH, Yang JS, Lu CC, et al. Effect of DNA damage response by quinazolinone analogue HMJ-38 on human umbilical vein endothelial cells: evidence for γH2A.X and DNA-PK-dependent pathway. Hum Exp Toxicol. 2014,33(6):590-601. doi: 10.1177/0960327113504791
    Read this paper