DNMT3L antibody

GeneTex

DNMT3L antibody

9

WB: 1:500. IHC-P: 1:500. IP: 1:100. ELISA: 1:1000-1:3000. IHC: 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1.11 mg/ml

Unconjugated

DNMT3L

DNA methyltransferase 3 like

cytosine-5-methyltransferase 3-like protein; DNA (cytosine-5-)-methyltransferase 3-like; DNA (cytosine-5)-methyltransferase 3-like; human cytosine-5-methyltransferase 3-like protein

Rabbit

IgG

DNA (cytosine-5)-methyltransferase 3-like

DNMT 3L is a nuclear protein which has similarity to DNA methyltransferases, involved in de novo methylation of CpG islands. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1.

Human

-20°C or -80°C,2°C to 8°C

12352203