Donafenib (Sorafenib D3)

Biorbyt

Donafenib (Sorafenib D3) [1130115-44-4]

10

1130115-44-4

Research Use Only

C21H16CLF3N4O3

467.8434391

Sorafenib D3 (Bay 43-9006 D3) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 15 nM, 20 nM and 22 nM for Raf-1, mVEGFR-2, mVEGFR-3 and B-RAF, respectively.

[2H]C(NC(C1=NC=CC(OC2C=CC(NC(NC3C=CC(Cl)=C(C(F)(F)F)C=3)=O)=CC=2)=C1)=O)([2H])[2H]

12352200