Doramapimod [285983-48-4]

BPS Bioscience

Doramapimod

7

285983-48-4

Research Use Only

≥98%

C31H37N5O3

527.7 Da

Doramapimod is a protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. Doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK. Doramapimod also blocks proliferation of cells expressing BCR-ABL(T315I), with an IC50 of 2-3 microM.

-20°C

51202000