Doramapimod

MedChem Express

Doramapimod [285983-48-4]

10

285983-48-4

Research Use Only

99.98

C31H37N5O3

527.66

Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC 50 for p38alpha=38 nM, for p38beta=65 nM, for p38gamma=200 nM, and for p38delta=520 nM. Doramapimod has picomolar affinity for p38 kinase ( K d =0.1 nM). Doramapimod also inhibits B-Raf with an IC 50 of 83 nM [1] [2] .

O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3

-20°C,2°C to 8°C

12352200