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ProductsBack/DR4 antibody [DR-4-02] (Low Endotoxin)

DR4 antibody [DR-4-02] (Low Endotoxin)

GTX00590-00

ApplicationsFunctional Assay, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry

Product group Antibodies

ReactivityHuman

TargetTNFRSF10A

Overview

Supplier
GeneTex
Product Name
DR4 antibody [DR-4-02] (Low Endotoxin)
Delivery Days Customer
9
Applications
Functional Assay, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
DR-4-02
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID8797
Target name
TNFRSF10A
Target description
TNF receptor superfamily member 10a
Target synonyms
APO2, CD261, DR4, TRAILR-1, TRAILR1, tumor necrosis factor receptor superfamily member 10A, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1, cytotoxic TRAIL receptor, death receptor 4, tumor necrosis factor receptor superfamily, member 10a
Host
Mouse
Isotype
IgG1
Protein IDO00220
Protein Name
Tumor necrosis factor receptor superfamily member 10A
Scientific Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Reactivity
Human
Storage Instruction
2°C to 8°C
UNSPSC
12352203

References

Yagolovich AV, Artykov AA, Karmakova TA, et al. Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile. Transl Oncol. 2020,13(4):100762. doi: 10.1016/j.tranon.2020.100762
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