DR4 antibody

GeneTex

DR4 antibody

9

WB: 1 microg/mL. ICC/IF: 10 microg/mL. IHC-P: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

TNFRSF10A

TNF receptor superfamily member 10a

APO2, CD261, DR4, TRAILR-1, TRAILR1, tumor necrosis factor receptor superfamily member 10A, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1, cytotoxic TRAIL receptor, death receptor 4, tumor necrosis factor receptor superfamily, member 10a

Rabbit

IgG

Tumor necrosis factor receptor superfamily member 10A

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1and Fas. A novel cell death receptor was recently identified and designated DR4 (for death receptor4)(1). The ligand for this novel death receptor has been identified and termed TRAIL (2,3), which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1)(4). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4mediates apoptosis and NF-kB activation in many tissues and cells.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203