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The data was published in the journal Oncogene in 2017. PMID: 28319065
The data was published in the journal Oncogene in 2017. PMID: 28319065
The data was published in the journal Oncogene in 2017. PMID: 28319065

Drebrin antibody

GTX11068
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
TargetDBN1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Drebrin antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1,000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID1627
  • Target name
    DBN1
  • Target description
    drebrin 1
  • Target synonyms
    D0S117E; developmentally-regulated brain protein; drebrin; drebrin A; drebrin E; drebrin E2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ16643
  • Protein Name
    Drebrin
  • Scientific Description
    The cortical cytoskeleton, a highly cross-linked submembranal F-actin filament network, plays an important role in cell proliferation, differentiation, migration, cell morphology and oncogenic transformation. Drebrin (developmentally-regulated brain protein) is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. Three major isoforms of drebrin, resulting from alternative splicing of a single gene, have been identified in the brain: the embryonic isoforms designated E1 and E2 and the adult or A isoform (95-120 kDa). An additional truncated form of drebrin A, s-drebrin/A2 (42 kDa), is specifically expressed in the adult brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites.
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • The drebrin/EB3 pathway drives invasive activity in prostate cancer. Dart AE et al., 2017 Jul 20, Oncogene
    Read more

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Figure 1. Western blot analysis of Drebrin/DBN1 using anti-Drebrin/DBN1 antibody (A05530-1). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human Hela whole cell lysates, Lane 2: human K562 whole cell lysates, Lane 3: human Jurkat whole cell lysates, Lane 4: monkey COS-7 whole cell lysates, Lane 5: rat brain tissue lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-Drebrin/DBN1 antigen affinity purified polyclonal antibody (Catalog # A05530-1) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for Drebrin/DBN1 at approximately 120 kDa. The expected band size for Drebrin/DBN1 is at 120 kDa.
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