DRI-C21045

MedChem Express

DRI-C21045 [2101765-81-3]

9

2101765-81-3

Research Use Only

99.02

C32H24N2O7S

580.61

DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC 50 of 0.17 microM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-kappaB and B cell proliferation all induced by CD40L with IC 50 s of 17.1 microM and 4.5 microM, respectively [1] .

O=S(C1=CC=CC2=CC=CC(NC(C3=CC=C(C4=CC=C(NC(C5=CC=C(C(OC)=O)C=C5)=O)C=C4)C=C3)=O)=C21)(O)=O

-20°C,2°C to 8°C

12352200