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DS-1205b (free base)

HY-114357A
MedChem Express
CAS Number1855860-24-0
DownloadMSDS
Product group Chemicals
Estimated Purity99.92
Molecular Weight735.80
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Overview

  • Supplier
    MedChem Express
  • Product Name
    DS-1205b (free base) [1855860-24-0]
  • Delivery Days Customer
    10
  • CAS Number
    1855860-24-0
  • Certification
    Research Use Only
  • Estimated Purity
    99.92
  • Molecular Formula
    C41H42FN5O7
  • Molecular Weight
    735.80
  • Scientific Description
    DS-1205b free base is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205b free base also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205b free base can inhibit cell migration in vitro and tumor growth in vivo[1].
  • SMILES
    O=C(C1=CN(CC2CCOCC2)C=C(C3=NC=C(C)C=C3)C1=O)NC4=CC=C(C5=CC(C6=CC=C(OC[C@@H]7OCCOC7)C(OC)=C6)=CN=C5N)C(F)=C4
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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