Dysferlin antibody [Ham3/17B2]
![Research Use Only](static/images/certificates/ruo.jpg)
GTX01941
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetDYSF
Overview
- SupplierGeneTex
- Product NameDysferlin antibody [Ham3/17B2]
- Delivery Days Customer9
- Antibody SpecificityReactive with the dysferlin molecule in human skeletal muscle. Also present in many non-muscle tissues.
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDHam3/17B2
- ConjugateUnconjugated
- Gene ID8291
- Target nameDYSF
- Target descriptiondysferlin
- Target synonymsdysferlin; dystrophy-associated fer-1-like 1; FER1L1; fer-1-like family member 1; fer-1-like protein 1; LGMD2B; LGMDR2; limb girdle muscular dystrophy 2B (autosomal recessive); MMD1
- HostMouse
- IsotypeIgG2b
- Scientific DescriptionThe protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2008]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203