Edicotinib [1142363-52-7]
HY-109086
CAS Number1142363-52-7
Product group Chemicals
Estimated Purity98.14%
Molecular Weight461.6
Overview
- SupplierMedChem Express
- Product NameEdicotinib [1142363-52-7]
- Delivery Days Customer10
- CAS Number1142363-52-7
- Estimated Purity98.14%
- Molecular FormulaC27H35N5O2
- Molecular Weight461.6
- Scientific DescriptionEdicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively. Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib has the potential for Alzheimers disease and rheumatoid arthritis research.
- SMILESO=C(C1=NC=C(C#N)N1)NC2=C(C3=CCC(C)(C)CC3)N=C(C(CC(C)(C)O4)CC4(C)C)C=C2
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200