Edicotinib

MedChem Express

Edicotinib [1142363-52-7]

10

1142363-52-7

Research Use Only

98.78

C27H35N5O2

461.60

Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active? colony-stimulating factor-1 receptor (CSF-1R) ?inhibitor with an IC 50 of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC 50 values of 20 nM and 190 nM, respectively [1] . Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration?in mice. Edicotinib has the potential for Alzheimers disease and rheumatoid arthritis research [1] [2] .

O=C(C1=NC=C(C#N)N1)NC2=C(C3=CCC(C)(C)CC3)N=C(C(CC(C)(C)O4)CC4(C)C)C=C2

-20°C,2°C to 8°C

12352200