Edicotinib [1142363-52-7]

TargetMol Chemicals

Edicotinib [1142363-52-7]

9

1142363-52-7

Chemical

Research Use Only

Edicotinib

98.58%

C27H35N5O2

461.6

Edicotinib (JNJ-527) is a blood-brain-penetrating, orally active, selective CSF-1R inhibitor (IC50 value is 3.2 nM), with less inhibitory effects on KIT (IC50 value is 20 nM) and FLT3 (IC50 value is 190 nM). Edicotinib (JNJ-527) can block microglial proliferation and attenuate neurodegeneration, and can be used to study Alzheimers disease and rheumatoid arthritis.

3 years

CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)OC(C)(C)C1

-20°C

12352200