EFCAB4B antibody

GeneTex

EFCAB4B antibody

9

WB: 1 microg/mL. IHC-P: 10 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

CRACR2A

calcium release activated channel regulator 2A

Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; calcium release-activated calcium channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; EFCAB4B; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; RAB46; ras-related protein Rab-46

Rabbit

IgG

EF-hand calcium-binding domain-containing protein 4B

EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203