EHT 1864

MedChem Express

EHT 1864 [754240-09-0]

10

754240-09-0

Research Use Only

99.85

C25H29Cl2F3N2O4S

581.48

EHT 1864 is an inhibitor of Rac family small GTPases . EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The K d values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Abeta 40 and Abeta 42 production in vivo. EHT 1864 dependently suppresses the release of migrasomes from podocytes induced by LPS, PAN, or HG [1] [2] [3] [4] .

O=C1C=C(CN2CCOCC2)OC=C1OCCCCCSC3=CC=NC4=CC(C(F)(F)F)=CC=C34.[H]Cl.[H]Cl

2°C to 8°C

12352200