GTX633631 WB Image
eIF3H / EIF3S3 antibody [GT35512]
GTX633631
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameeIF3H / EIF3S3 antibody [GT35512]
- Delivery Days Customer9
- CertificationResearch Use Only
- Clone IDGT35512
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203