EIF3I Antibody

Cusabio

EIF3I Antibody

20

ImmunoFluorescence, Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

EIF3I

eukaryotic translation initiation factor 3 subunit I

EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36, eukaryotic translation initiation factor 3 subunit I, TGF-beta receptor-interacting protein 1, TGFbeta receptor-interacting protein 1, eukaryotic translation initiation factor 3 subunit 2, eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD), eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa, predicted protein of HQ2242

Rabbit

IgG

Eukaryotic translation initiation factor 3 subunit I

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Human, Rat

-20°C or -80°C

41116161