ProductsBack/EpCAM antibody [VU-1D9]

IHC-P analysis of human breast carcinoma tissue using GTX28667 EpCAM antibody [VU-1D9].

EpCAM antibody [VU-1D9]

GTX28667

ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman

TargetEPCAM

Overview

Supplier
GeneTex
Product Name
EpCAM antibody [VU-1D9]
Delivery Days Customer
9
Application Supplier Note
IHC-P: 1-2 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
VU-1D9
Concentration
200 ug/ml
Conjugate
Unconjugated
Gene ID4072
Target name
EPCAM
Target description
epithelial cell adhesion molecule
Target synonyms
Ber-Ep4, BerEp4, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, LYNCH8, M4S1, MIC18, MK-1, MOC-31, TACSTD1, TROP1, epithelial cell adhesion molecule, adenocarcinoma-associated antigen, cell surface glycoprotein Trop-1, epithelial glycoprotein 314, human epithelial glycoprotein-2, major gastrointestinal tumor-associated protein GA733-2, membrane component, chromosome 4, surface marker (35kD glycoprotein), trophoblast cell surface antigen 1, tumor-associated calcium signal transducer 1
Host
Mouse
Isotype
IgG1
Protein IDP16422
Protein Name
Epithelial cell adhesion molecule
Scientific Description
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
Reactivity
Human
Storage Instruction
2°C to 8°C
UNSPSC
12352203

References

Twigger AJ, Engelbrecht LK, Bach K, et al. Transcriptional changes in the mammary gland during lactation revealed by single cell sequencing of cells from human milk. Nat Commun. 2022,13(1):562. doi: 10.1038/s41467-021-27895-0
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Mikami H, Kawaguchi M, Huang CJ, et al. Virtual-freezing fluorescence imaging flow cytometry. Nat Commun. 2020,11(1):1162. doi: 10.1038/s41467-020-14929-2
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Yoshida M, Hibino K, Yamamoto S, et al. Preferential capture of EpCAM-expressing extracellular vesicles on solid surfaces coated with an aptamer-conjugated zwitterionic polymer. Biotechnol Bioeng. 2018,115(3):536-544. doi: 10.1002/bit.26489
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Kershaw S, Cummings J, Morris K, et al. Optimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells. BMC Cancer. 2015,15:387. doi: 10.1186/s12885-015-1382-y
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Lyberopoulou A, Aravantinos G, Efstathopoulos EP, et al. Mutational analysis of circulating tumor cells from colorectal cancer patients and correlation with primary tumor tissue. PLoS One. 2015,10(4):e0123902. doi: 10.1371/journal.pone.0123902
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Ma R, Fredriksson I, Karthik GM, et al. Superficial scrapings from breast tumors is a source for biobanking and research purposes. Lab Invest. 2014,94(7):796-805. doi: 10.1038/labinvest.2014.65
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Chen HH, Lin MW, Tien WT, et al. High-purity separation of cancer cells by optically induced dielectrophoresis. J Biomed Opt. 2014,19(4):045002. doi: 10.1117/1.JBO.19.4.045002
Read this paper
Okuda H, Kobayashi A, Xia B, et al. Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells. Cancer Res. 2012,72(2):537-47. doi: 10.1158/0008-5472.CAN-11-1678
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Kimura O, Takahashi T, Ishii N, et al. Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines. Cancer Sci. 2010,101(10):2145-55. doi: 10.1111/j.1349-7006.2010.01661.x
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EpCAM antibody [VU-1D9]

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