Bio-Connect

Estrogen Receptor alpha antibody [1F3]

GTX70171
GeneTex
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman, Rabbit
TargetESR1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Estrogen Receptor alpha antibody [1F3] - Comparison, Overexpression Validated
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody is specific for ER alpha protein, and it does not cross react with ER beta protein.
  • Application Supplier Note
    WB: 1:500-1:3000. IP: 1 - 5 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    1F3
  • Concentration
    1.56 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2099
  • Target name
    ESR1
  • Target description
    estrogen receptor 1
  • Target synonyms
    E2 receptor alpha; ER; Era; ER-alpha; ESR; ESRA; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; ESTRR; NR3A1; nuclear receptor subfamily 3 group A member 1; oestrogen receptor alpha
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP03372
  • Protein Name
    Estrogen receptor
  • Scientific Description
    This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
  • Reactivity
    Human, Rabbit
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Tamoxifen Rechallenge Decreases Metastatic Potential but Increases Cell Viability and Clonogenicity in a Tamoxifen-Mediated Cytotoxicity-Resistant Subline of Human Breast MCF7 Cancer Cells. Chang YC et al., 2020, Front Cell Dev Biol
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  • Targeting claudin-3 suppresses stem cell-like phenotype in nonsquamous non-small-cell lung carcinoma. Ma L et al., 2019 Feb, Lung Cancer Manag
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  • AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment. Daurio NA et al., 2016 Jun 1, Cancer Res
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  • ACK1 tyrosine kinase interacts with histone demethylase KDM3A to regulate the mammary tumor oncogene HOXA1. Mahajan K et al., 2014 Oct 10, J Biol Chem
    Read more
  • Activity and intracellular location of estrogen receptors alpha and beta in human bronchial epithelial cells. Ivanova MM et al., 2009 Jun 16, Mol Cell Endocrinol
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  • Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Sun M et al., 2008 Mar, Mol Cancer Ther
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  • Estrogen and phytoestrogen predispose to erectile dysfunction: do ER-alpha and ER-beta in the cavernosum play a role? Srilatha B et al., 2004 Feb, Urology
    Read more