Estrogen Receptor alpha antibody [1F3]
GTX70171
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman, Rabbit
TargetESR1
Overview
- SupplierGeneTex
- Product NameEstrogen Receptor alpha antibody [1F3] - Comparison, Overexpression Validated
- Delivery Days Customer9
- Antibody SpecificityThis antibody is specific for ER alpha protein, and it does not cross react with ER beta protein.
- Application Supplier NoteWB: 1:500-1:3000. IP: 1 - 5 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID1F3
- Concentration1.56 mg/ml
- ConjugateUnconjugated
- Gene ID2099
- Target nameESR1
- Target descriptionestrogen receptor 1
- Target synonymsE2 receptor alpha; ER; Era; ER-alpha; ESR; ESRA; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; ESTRR; NR3A1; nuclear receptor subfamily 3 group A member 1; oestrogen receptor alpha
- HostMouse
- IsotypeIgG1
- Protein IDP03372
- Protein NameEstrogen receptor
- Scientific DescriptionThis gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
- ReactivityHuman, Rabbit
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Tamoxifen Rechallenge Decreases Metastatic Potential but Increases Cell Viability and Clonogenicity in a Tamoxifen-Mediated Cytotoxicity-Resistant Subline of Human Breast MCF7 Cancer Cells. Chang YC et al., 2020, Front Cell Dev BiolRead more
- Targeting claudin-3 suppresses stem cell-like phenotype in nonsquamous non-small-cell lung carcinoma. Ma L et al., 2019 Feb, Lung Cancer ManagRead more
- AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment. Daurio NA et al., 2016 Jun 1, Cancer ResRead more
- ACK1 tyrosine kinase interacts with histone demethylase KDM3A to regulate the mammary tumor oncogene HOXA1. Mahajan K et al., 2014 Oct 10, J Biol ChemRead more
- Activity and intracellular location of estrogen receptors alpha and beta in human bronchial epithelial cells. Ivanova MM et al., 2009 Jun 16, Mol Cell EndocrinolRead more
- Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Sun M et al., 2008 Mar, Mol Cancer TherRead more
- Estrogen and phytoestrogen predispose to erectile dysfunction: do ER-alpha and ER-beta in the cavernosum play a role? Srilatha B et al., 2004 Feb, UrologyRead more