F-1 [2244775-31-1]

MedChem Express

F-1 [2244775-31-1]

10

2244775-31-1

Research Use Only

98.03

C22H27ClN8O3S

519.02

F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively[1].

O=S(NC1=C(NC2=NC(NC3=C(OC)N=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)C=CC=C1)(C)=O

2°C to 8°C

12352200