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ProductsBack/FACL4 antibody [C3], C-term

FACL4 antibody [C3], C-term

GTX100260
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetACSL4
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Overview

  • Supplier
    GeneTex
  • Product Name
    FACL4 antibody [C3], C-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:1000-1:5000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.37 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2182
  • Target name
    ACSL4
  • Target description
    acyl-CoA synthetase long chain family member 4
  • Target synonyms
    ACS4; acyl-CoA synthetase 4; arachidonate--CoA ligase; FACL4; fatty-acid-Coenzyme A ligase, long-chain 4; LACS4; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; long-chain-fatty-acid--CoA ligase 4; MRX63; MRX68; XLID63
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO60488
  • Protein Name
    Long-chain-fatty-acid--CoA ligase 4
  • Scientific Description
    The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers. Soula M et al., 2020 Dec, Nat Chem Biol
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  • Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases. Ndiaye H et al., 2020 Apr 30, Biosci Rep
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  • Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex. Chen X et al., 2020 Nov, FEBS J
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  • Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Garcia-Bermudez J et al., 2019 Mar, Nature
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  • The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells. Radif Y et al., 2018 Nov, Mol Cell Biochem
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  • Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling. Filadi R et al., 2015 Apr 28, Proc Natl Acad Sci U S A
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