FACL4 antibody [C3], C-term
GTX100260
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetACSL4
Overview
- SupplierGeneTex
- Product NameFACL4 antibody [C3], C-term
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:1000-1:5000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.37 mg/ml
- ConjugateUnconjugated
- Gene ID2182
- Target nameACSL4
- Target descriptionacyl-CoA synthetase long chain family member 4
- Target synonymsACS4, FACL4, LACS4, MRX63, MRX68, XLID63, long-chain-fatty-acid--CoA ligase 4, acyl-CoA synthetase 4, arachidonate--CoA ligase, fatty-acid-Coenzyme A ligase, long-chain 4, lignoceroyl-CoA synthase, long-chain acyl-CoA synthetase 4, long-chain fatty-acid-Coenzyme A ligase 4
- HostRabbit
- IsotypeIgG
- Protein IDO60488
- Protein NameLong-chain-fatty-acid--CoA ligase 4
- Scientific DescriptionThe protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Soula M, Weber RA, Zilka O, et al. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers. Nat Chem Biol. 2020,16(12):1351-1360. doi: 10.1038/s41589-020-0613-yRead this paper
- Ndiaye H, Liu JY, Hall A, et al. Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases. Biosci Rep. 2020,40(4). doi: 10.1042/BSR20200219Read this paper
- Chen X, Li D, Sun HY, et al. Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex. FEBS J. 2020,287(21):4747-4766. doi: 10.1111/febs.15266Read this paper
- Garcia-Bermudez J, Baudrier L, Bayraktar EC, et al. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. 2019,567(7746):118-122. doi: 10.1038/s41586-019-0945-5Read this paper
- Radif Y, Ndiaye H, Kalantzi V, et al. The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells. Mol Cell Biochem. 2018,448(1-2):275-286. doi: 10.1007/s11010-018-3332-xRead this paper
- Filadi R, Greotti E, Turacchio G, et al. Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling. Proc Natl Acad Sci U S A. 2015,112(17):E2174-81. doi: 10.1073/pnas.1504880112Read this paper




