FAM59A antibody

GeneTex

FAM59A antibody

9

WB: 1 - 2 microg/mL. IHC-P: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

GAREM1

GRB2 associated regulator of MAPK1 subtype 1

C18orf11, FAM59A, GAREM, Gm944, GRB2-associated and regulator of MAPK protein 1, GRB2 associated regulator of MAPK1 1, GRB2 associated, regulator of MAPK1, GRB2-associated and regulator of MAPK1, Grb2-associated and regulator of Erk/MAPK, family with sequence similarity 59, member A, protein FAM59A

Rabbit

IgG

GRB2-associated and regulator of MAPK protein 1

FAM59A, also known as GAREM, was initially identified through a mass spectroscoptic method that measures different phosphotyrosine states of proteins in response to different cell stimuli. FAM59A is a downstream molecule in the EGF signaling pathway that is tyrosine-phosphorylated, and this phosphorylation is needed for the binding of Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. ERK activation in response to EGF stimulation is regulated by FAM59A in COS-7 and HeLa cells, and the overexpression of FAM59A stimulated cell proliferation and colony formation in soft agar, suggesting that FAM59A might be a critical protein with roles in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203