IHC-P analysis of human brain tissue using GTX85231 FAM59A antibody. Working concentration : 5 microg/ml
FAM59A antibody
GTX85231
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetGAREM1
Overview
- SupplierGeneTex
- Product NameFAM59A antibody
- Delivery Days Customer9
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID64762
- Target nameGAREM1
- Target descriptionGRB2 associated regulator of MAPK1 subtype 1
- Target synonymsC18orf11; FAM59A; family with sequence similarity 59, member A; GAREM; Gm944; GRB2 associated regulator of MAPK1 1; GRB2 associated, regulator of MAPK1; Grb2-associated and regulator of Erk/MAPK; GRB2-associated and regulator of MAPK protein 1; GRB2-associated and regulator of MAPK1; protein FAM59A
- HostRabbit
- IsotypeIgG
- Scientific DescriptionFAM59A, also known as GAREM, was initially identified through a mass spectroscoptic method that measures different phosphotyrosine states of proteins in response to different cell stimuli. FAM59A is a downstream molecule in the EGF signaling pathway that is tyrosine-phosphorylated, and this phosphorylation is needed for the binding of Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. ERK activation in response to EGF stimulation is regulated by FAM59A in COS-7 and HeLa cells, and the overexpression of FAM59A stimulated cell proliferation and colony formation in soft agar, suggesting that FAM59A might be a critical protein with roles in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.
- ReactivityHuman, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203