Fasudil dihydrochloride [203911-27-7]

TargetMol Chemicals

Fasudil dihydrochloride [203911-27-7]

44

203911-27-7

Research Use Only

Fasudil dihydrochloride

C14H19Cl2N3O2S

364.29

Fasudil dihydrochloride, also known as HA-1077 and AT877, is a nonspecific inhibitor of RhoA/ROCK. It exhibits inhibitory effects on protein kinases, including ROCK1 with a Ki value of 0.33 microM, as well as ROCK2, PKA, PKC, and PKG with IC 50 values of 0.158 microM, 4.58 microM, 12.30 microM, and 1.650 microM, respectively. Additionally, Fasudil dihydrochloride demonstrates potent Ca 2+ channel blocking activity and acts as a vasodilator [1] [2] [3].

3 years

Cl.Cl.O=S(=O)(N1CCCNCC1)c1cccc2cnccc12

-20°C

12352200