FBXW5 Antibody, HRP conjugated

Cusabio

FBXW5 Antibody, HRP conjugated

20

ELISA

Research Use Only

Polyclonal

HRP

FBXW5

F-box and WD repeat domain containing 5

F-box and WD-40 domain-containing protein 5; F-box/WD repeat-containing protein 5; Fbw5; WD repeat-containing F-box protein FBW5

Rabbit

IgG

F-box/WD repeat-containing protein 5

Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.

Human

-20°C or -80°C

12352203