Fc (human):Dectin-1 (mouse) (rec.)

AdipoGen Life Sciences

Fc (human):Dectin-1 (mouse) (rec.)

10

Research Use Only

1 mg/ml

>95%

C-type lectin domain family 7 member A

Dectin-1 and dectin-2 are type II transmembrane proteins of the C-type lectin family. They contain single carbohydrate recognition domains (CRDs) in their extracellular region. Dectin-1 and dectin-2 are expressed in macrophages and dendritic cells. Dectin-1 recognizes beta-glucans with its CRD and signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domain, whereas dectin-2 recognizes alpha-mannans and transduces its signal through association with the ITAM-containing Fc receptor gamma-chain. Dectin-1 controls fungal infection by sensing beta-glucans and by mounting a Th17-mediated immune responses. Dectin-1 seems to detect also non-fungal ligands such as invertebrate tropomyosin. Dectin-1 by binding to non-fungal ligands controls type 2 immunity in the lungs in response to the dust mite aeroallergen through the regulation of IL-33-driven IL-13 production from innate lymphoid cells. - Protein. Mouse dectin-1 (aa 72-244) is fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.01EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Purity: >95% (SDS-PAGE). Dectin-1 and dectin-2 are type II transmembrane proteins of the C-type lectin family. They contain single carbohydrate recognition domains (CRDs) in their extracellular region. Dectin-1 and dectin-2 are expressed in macrophages and dendritic cells. Dectin-1 recognizes beta-glucans with its CRD and signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domain, whereas dectin-2 recognizes alpha-mannans and transduces its signal through association with the ITAM-containing Fc receptor gamma-chain.

-20°C,2°C to 8°C

12352202