Western blot analysis of extracts of various cell lines using FEN1 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of various cell lines using FEN1 Polyclonal Antibody at dilution of 1:1000.
FEN1 Polyclonal Antibody
E-AB-60232
Product group Antibodies
Overview
- SupplierElabscience
- Product NameFEN1 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThe protein encoded by this gene removes 5 overhanging flaps in DNA repair and processes the 5 ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5 end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
- UNSPSC12352203