Bio-Connect

FGF9 antibody [FG9-77]

Research Use Only
GTX10424
GeneTex
ApplicationsDot Blot, Western Blot, ELISA
Product group Antibodies
ReactivityHuman, Mouse
TargetFGF9
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    FGF9 antibody [FG9-77]
  • Delivery Days Customer
    9
  • Antibody Specificity
    The antibody reacts specifically with recombinant FGF-9. It does not cross-react with human acidic FGF or basic FGF.
  • Applications
    Dot Blot, Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    FG9-77
  • Conjugate
    Unconjugated
  • Gene ID2254
  • Target name
    FGF9
  • Target description
    fibroblast growth factor 9
  • Target synonyms
    FGF-9; fibroblast growth factor 9; fibroblast growth factor 9 (glia-activating factor); GAF; HBFG-9; HBGF-9; heparin-binding growth factor 9; SYNS3
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    The FGF family consists of at least nine members (FGF1 to FGF9), with a 30-50% sequence identity at the amino acid level. All besides FGF8 contain two conserved positions of two cysteine residues. FGF9, also known as glia activating factor (GAF), was initially identified in the culture supernatant of a human glioma cell line as having the capability to promote glial cell proliferation. FGF9 is a heparin binding molecule, which is a glycosylated single polypeptide of 208 amino acids (23-30 kD, depending on rate of glycosylation), with a 30% sequence similarity with other members of the FGF family. The molecule is conserved across species (rat FGF9 is 94% identical to the human molecule). FGF9 has a unique spectrum of activity on cells, and it acts on the central nervous system. Although it has a mitogenic effect on fibroblasts like other FGFs, FGF9 has no effect on human umbilical vein endothelial cells. FGF9 stimulates the proliferation of oligodendrocyte type 2 astrocyte progenitor cells, Balb/c 3T3 fibroblasts and rat pheochromacytoma cell line PC-12. Human FGF9 is oncogenic when transfected into murine fibroblasts. Studies have identified FGF9 expression in brain and kidney. FGF9 binds specifically to FGF receptors 2 and 3, but not to FGF receptors 1 and 4. Like all other FGF ligands, FGF9 requires heparin sulfate for high affinity receptor binding and biological activities.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203