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Filgotinib

HY-18300
MedChem Express
CAS Number1206161-97-8
Product group Chemicals
Estimated Purity99.44
Molecular Weight425.50
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Filgotinib [1206161-97-8]
  • Delivery Days Customer
    10
  • CAS Number
    1206161-97-8
  • Certification
    Research Use Only
  • Estimated Purity
    99.44
  • Molecular Formula
    C21H23N5O3S
  • Molecular Weight
    425.50
  • Scientific Description
    Filgotinib (GLPG0634) is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. Filgotinib can effectively inhibit the activities of JAK1 , JAK2 , JAK3 and TYK2 with IC 50 values of 10 nM, 28 nM, 810 nM and 116 nM, respectively. Filgotinib also inhibits HIV-1 driven gene transcription and reduces proliferation of HIV-1 infected cells. Filgotinib can be used in the study of rheumatoid arthritis and inflammatory bowel disease [1] [2] [3] .
  • SMILES
    O=C(C1CC1)NC2=NN3C(C4=CC=C(CN5CCS(CC5)(=O)=O)C=C4)=CC=CC3=N2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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