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ProductsBack/GLPG0634 [1206161-97-8]
Chemical Structure
Chemical Structure
Chemical Structure

GLPG0634 [1206161-97-8]

SYN-1158
SYNkinase
CAS Number1206161-97-8
Product group Chemicals
Estimated Purity>95%
Molecular Weight425.5
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Overview

  • Supplier
    SYNkinase
  • Product Name
    GLPG0634 [1206161-97-8]
  • Delivery Days Customer
    10
  • CAS Number
    1206161-97-8
  • Estimated Purity
    >95%
  • Molecular Formula
    C21H23N5O3S
  • Molecular Weight
    425.5
  • Scientific Description
    Chemical. CAS: 1206161-97-8. Formula: C21H23N5O3S. MW: 425.5. GLPG0634 is a novel and specific inhibitor of JAK1 and JAK2 with IC(50) of 10nM and 28nM respectively measured by in vitro kinase assays (ATP 2microM). In particular GLPG0634, while being a potent inhibitor of JAK1 and JAK2 does not inhibit TYK2 or JAK3, and GLPG0634 exhibits a dramatically improved in vivo potency over structurally similar compounds. May be used for the prevention of variety of conditions in animals including inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation and/or diseases associated with hypersecretion of IL-6. - GLPG0634 is a novel and specific inhibitor of JAK1 and JAK2 with IC(50) of 10nM and 28nM respectively measured by in vitro kinase assays (ATP 2microM). In particular GLPG0634, while being a potent inhibitor of JAK1 and JAK2 does not inhibit TYK2 or JAK3, and GLPG0634 exhibits a dramatically improved in vivo potency over structurally similar compounds. May be used for the prevention of variety of conditions in animals including inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation and/or diseases associated with hypersecretion of IL-6.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000