Fluzoparib [1358715-18-0]

MedChem Express

Fluzoparib [1358715-18-0]

10

1358715-18-0

Research Use Only

99.96

C22H16F4N6O2

472.40

Fluzoparib (SHR3162) is a potent and orally active PARP1 inhibitor (IC50=1.46+/-0.72 nM, a cell-free enzymatic assay) with superior antitumor activity. Fluzoparib selectively inhibits the proliferation of homologous recombination repair (HR)-deficient cells, and sensitizes both HR-deficient and HR-proficient cells to cytotoxic agents. Fluzoparib exhibits good pharmacokinetic properties in vivo and can be used for BRCA1/2-mutant relapsed ovarian cancer research[1].

O=C1NN=C(CC2=CC=C(F)C(C(N3CC4=NC(C(F)(F)F)=NN4CC3)=O)=C2)C5=C1C=CC=C5

-20°C,2°C to 8°C

12352200