FM-479 [2226521-64-6]

MedChem Express

FM-479 [2226521-64-6]

10

2226521-64-6

Research Use Only

99.2

C25H26N6O2

442.51

FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

O=C(N(C)C)/C(C#N)=C/C1=CC=C(C2=NC3=CN=C(N(C)C=C4)C4=C3N2C5CCCCC5)O1

-20°C,2°C to 8°C

12352200