Frataxin Antibody / FXN

Biorbyt

Frataxin Antibody / FXN

10

Optimal dilution of the Frataxin antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1) IHC-P, WB

Research Use Only

Monoclonal

FDAX-1

Unconjugated

FXN

frataxin

CyaY, FA, FARR, FRDA, X25, frataxin, mitochondrial, Friedreich ataxia protein

Mouse

IgG2b

Frataxin, mitochondrial

Reduced expression of frataxin is the cause of Friedreichs ataxia (FRDA), a lethal neurodegenerative disease. The reduction in frataxin gene expression may be attributable from either the silencing of transcription of the frataxin gene because of epigenetic modifications in the chromosomal entity or from the inability of splicing the expanded GAA repeats in the first intron of the pre-mRNA as seen in bacteria and human cells or both. The expansion of intronic trinucleotide repeat GAA results in Friedreichs ataxia. [Wiki]

Human

-20°C,2°C to 8°C

12352203