FzM1 [1680196-54-6]

MedChem Express

FzM1 [1680196-54-6]

10

1680196-54-6

Research Use Only

98.72

C21H16N2O2S

360.43

FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh= 6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/beta-catenin cascade[1][2].

O=C(NC1=CC2=CC=CC=C2C=C1)NC3=CC(O)=CC(C4=CC=CS4)=C3

-20°C

12131703