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FzM1

HY-116553
MedChem Express
CAS Number1680196-54-6
DownloadMSDS
Product group Chemicals
Estimated Purity98.62
Molecular Weight360.43
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Overview

  • Supplier
    MedChem Express
  • Product Name
    FzM1 [1680196-54-6]
  • Delivery Days Customer
    10
  • CAS Number
    1680196-54-6
  • Certification
    Research Use Only
  • Estimated Purity
    98.62
  • Molecular Formula
    C21H16N2O2S
  • Molecular Weight
    360.43
  • Scientific Description
    FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh= 6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/beta-catenin cascade[1][2].
  • SMILES
    O=C(NC1=CC2=CC=CC=C2C=C1)NC3=CC(O)=CC(C4=CC=CS4)=C3
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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