Western blot All lanes: FZR1 antibody at 6ug/ml Lane 1: Hela whole cell lysate Lane 2: Jurkat whole cell lysate Lane 3: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 56, 55, 45 kDa Observed band size: 56 kDa

FZR1 Antibody

Name: FZR1 Antibody
SKU: CSB-PA892473LA01HU_C90
Availability: BackOrder

CSB-PA892473LA01HU

ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman

TargetFZR1

Overview

Supplier
Cusabio
Product Name
FZR1 Antibody
Delivery Days Customer
20
Applications
Western Blot, ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID51343
Target name
FZR1
Target description
fizzy and cell division cycle 20 related 1
Target synonyms
CDC20 homolog 1; CDC20C; CDC20-like 1b; CDC20-like protein 1; CDH1; cdh1/Hct1 homolog; fizzy/cell division cycle 20 related 1; fizzy-related protein homolog; FZR; FZR2; HCDH; HCDH1
Host
Rabbit
Isotype
IgG
Protein IDQ9UM11
Protein Name
Fizzy-related protein homolog
Scientific Description
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Reactivity
Human
Storage Instruction
-20°C or -80°C
UNSPSC
41116161

FZR1 Antibody

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Overview

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