FZR1 antibody

GeneTex

FZR1 antibody

9

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.26 mg/ml

Unconjugated

FZR1

fizzy and cell division cycle 20 related 1

CDC20 homolog 1; CDC20C; CDC20-like 1b; CDC20-like protein 1; CDH1; cdh1/Hct1 homolog; fizzy/cell division cycle 20 related 1; fizzy-related protein homolog; FZR; FZR2; HCDH; HCDH1

Rabbit

IgG

Fizzy-related protein homolog

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203