Gamma Catenin Antibody / Plakoglobin

Biorbyt

Gamma Catenin Antibody / Plakoglobin

10

The stated application concentrations are suggested starting amounts. Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml,Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT FACS, IF, IHC-P, WB

Research Use Only

Monoclonal

CTNG/1664

Unconjugated

JUP

junction plakoglobin

catenin (cadherin-associated protein), gamma 80kDa; CTNNG; desmoplakin III; desmoplakin-3; desmosomal protein 3; DP3; DPIII; junction plakoglobin; PDGB; PG; PKGB

Mouse

IgG1

Junction plakoglobin

Plakoglobin, also known as junction plakoglobin or gamma Catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous to beta-catenin. It is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in Gamma Catenin are associated with arrhythmogenic right ventricular dysplasia and Pemphigus vulgaris.Gamma Catenin is a major cytoplasmic component of both desmosomes and adherens junctions, and is the only known constituent common to submembranous plaques in both of these structures, which are located at the intercalated disc (ICD) of cardiomyocytes. It links cadherins to the actin cytoskeleton. Gamma Catenin binds to conserved regions of desmoglein and desmocollin at intracellular catenin-binding sites to assemble desmosomes. [Wiki]

Human

-20°C,2°C to 8°C

12352203