Gamma Catenin Antibody / Plakoglobin

Biorbyt

Gamma Catenin Antibody / Plakoglobin

16

Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunofluorescence: 1-2ug/ml,Western blot: 0.5-1ug/ml,Flow cytometry: 1-2ug/million cells FACS, IF, WB

Research Use Only

Monoclonal

11E4.

Unconjugated

JUP

junction plakoglobin

CTNNG, DP3, DPIII, PDGB, PG, PKGB, junction plakoglobin, catenin (cadherin-associated protein), gamma 80kDa, desmoplakin III, desmoplakin-3, desmosomal protein 3

Mouse

IgG1

Junction plakoglobin

It recognizes a protein of 80-87kDa, identified as gamma-Catenin or Plakoglobin. The catenins (I+/-, beta, I3 and I) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. I+/- T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. I+/- T-catenin binds to I+/- E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for I+/--T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.

Human, Mouse

-20°C,2°C to 8°C

12352203