gamma-Secretase modulator 11 [2434630-29-0]

TargetMol Chemicals

gamma-Secretase modulator 11

72

2434630-29-0

Chemical

Research Use Only

gamma-Secretase modulator 11

C28H22F2N4O2

484.5

5-{8-[(3,4-Difluoro[1,1-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and brain exposure, significantly reduced brain Abeta42 levels, showed no inhibitory effect on cytochrome p450 enzymes, and demonstrated excellent anti-cognitive deficits in AD model mice.

3 years

CC1=C(N2C(C(OCC3=C(F)C=C(C=C3)C4=CC=C(F)C=C4)=CC=C2)=N1)C=5C=CC(C(NC)=O)=NC5

-20°C

12352204