Gartisertib

AbMole BioScience

Gartisertib

9

1613191-99-3

Research Use Only

C25H29F2N9O3

541.55

Gartisertib (VX-803) is an ATP-competitive, orally active, selective ATR inhibitor with Ki<150 pM. Gartisertib inhibits atR-driven phosphorylation of checkpoint kinase-1 (Chk1) with an IC50 value of 8 nM. It has antitumor activity.

NC1=N[N]2C=C(F)C=NC2=C1C(=O)NC3=C(N4CCC(CC4)C(=O)N5CCN(CC5)C6COC6)C(=CN=C3)F

12352200