GBL Antibody

Biorbyt

GBL Antibody

10

Provided assay concentrations are suggestions only, GBL antibody titration may be required for optimal results.

Western Blot

Western blot: 1-3ug/ml WB

Research Use Only

Polyclonal

Unconjugated

MLST8

MTOR associated protein MLST8

GBL, GbetaL, LST8, POP3, WAT1, target of rapamycin complex subunit LST8, MTOR associated protein, LST8 homolog, TORC subunit LST8, gable, mammalian lethal with SEC13 protein 8, protein GbetaL

Rabbit

IgG

GBL (G protein beta subunit-like), also called MLST8 (MTOR associated protein, LST8 homolog), is a subunit of the mTOR signaling complexes mTORC1 and mTORC2, which help regulate cell growth and survival in response to growth factor (mTORC1 & 2) and nutrient (mTORC1) signaling. It is required for the phosphorylation of S6 kinase and the signal adaptor protein Insulin receptor substrate 1 and S473 phosphorylation of AKT. GBL is also a regulator of TNFa-induced NF-kB activity, with overexpression inhibiting and down-regulation enhancing NF-kB signaling (Kim et al, 2008).

Human, Mouse, Rat

-20°C,2°C to 8°C

12352203