The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA929459(GCH1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA929459(GCH1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200)
GCH1 Antibody
CSB-PA929459
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetGCH1
Overview
- SupplierCusabio
- Product NameGCH1 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID2643
- Target nameGCH1
- Target descriptionGTP cyclohydrolase 1
- Target synonymsdystonia 14; DYT14; DYT5; DYT5a; GCH; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTPCH1; GTP-CH-1; GTP-CH-I; guanosine 5'-triphosphate cyclohydrolase I; HPABH4B
- HostRabbit
- IsotypeIgG
- Protein IDP30793
- Protein NameGTP cyclohydrolase 1
- Scientific DescriptionThis gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC41116161
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