GCLM antibody
GTX114075
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetGCLM
Overview
- SupplierGeneTex
- Product NameGCLM antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:10000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.21 mg/ml
- ConjugateUnconjugated
- Gene ID2730
- Target nameGCLM
- Target descriptionglutamate-cysteine ligase modifier subunit
- Target synonymsGLCLR, glutamate--cysteine ligase regulatory subunit, GCS light chain, GSC light chain, gamma-ECS regulatory subunit, gamma-glutamylcysteine synthetase regulatory subunit, glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD), glutamate-cysteine ligase modifier subunit delta2 alternative splicing, glutamate-cysteine ligase regulatory protein
- HostRabbit
- IsotypeIgG
- Protein IDP48507
- Protein NameGlutamate--cysteine ligase regulatory subunit
- Scientific DescriptionGlutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Yoon SJ, Combs JA, Falzone A, et al. Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors. Cancer Res. 2023,83(9):1426-1442. doi: 10.1158/0008-5472.CAN-22-3000Read this paper
- Forcina GC, Pope L, Murray M, et al. Ferroptosis regulation by the NGLY1/NFE2L1 pathway. Proc Natl Acad Sci U S A. 2022,119(11):e2118646119. doi: 10.1073/pnas.2118646119Read this paper
- NandyMazumdar M, Paranjapye A, Browne J, et al. BACH1, the master regulator of oxidative stress, has a dual effect on CFTR expression. Biochem J. 2021,478(20):3741-3756. doi: 10.1042/BCJ20210252Read this paper
- Hori Y, Tsutsumi R, Nasu K, et al. Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities. Cells. 2021,10(5). doi: 10.3390/cells10051090Read this paper
- Hseu YC, Vudhya Gowrisankar Y, Wang LW, et al. The in vitro and in vivo depigmenting activity of pterostilbene through induction of autophagy in melanocytes and inhibition of UVA-irradiated α-MSH in keratinocytes via Nrf2-mediated antioxidant pathways. Redox Biol. 2021,44:102007. doi: 10.1016/j.redox.2021.102007Read this paper
- Rabinowitz J, Sharifi HJ, Martin H, et al. xCT/SLC7A11 antiporter function inhibits HIV-1 infection. Virology. 2021,556:149-160. doi: 10.1016/j.virol.2021.01.008Read this paper
- Rojas-Morales P, Tapia E, León-Contreras JC, et al. Mechanisms of Fasting-Mediated Protection against Renal Injury and Fibrosis Development after Ischemic Acute Kidney Injury. Biomolecules. 2019,9(9). doi: 10.3390/biom9090404Read this paper
- Huang SY, Chang SF, Chau SF, et al. The Protective Effect of Hispidin against Hydrogen Peroxide-Induced Oxidative Stress in ARPE-19 Cells via Nrf2 Signaling Pathway. Biomolecules. 2019,9(8). doi: 10.3390/biom9080380Read this paper
- Wu CT, Deng JS, Huang WC, et al. Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling. Oxid Med Cell Longev. 2019,2019:9056845. doi: 10.1155/2019/9056845Read this paper
- Wu YL, Chang JC, Lin WY, et al. Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway. Free Radic Biol Med. 2018,115:309-317. doi: 10.1016/j.freeradbiomed.2017.12.011Read this paper
Datasheet
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