WB analysis of various sample lysates using GTX32624 GDF8 / Myostatin antibody. Dilution : 1:1000 Loading : 25microg per lane
WB analysis of various sample lysates using GTX32624 GDF8 / Myostatin antibody. Dilution : 1:1000 Loading : 25microg per lane
GDF8 / Myostatin antibody
GTX32624
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMSTN
Overview
- SupplierGeneTex
- Product NameGDF8 / Myostatin antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500 - 1:2000. IHC-P: 1:50 - 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID2660
- Target nameMSTN
- Target descriptionmyostatin
- Target synonymsGDF8, MSLHP, growth/differentiation factor 8, myostatin-b
- HostRabbit
- IsotypeIgG
- Protein IDO14793
- Protein NameGrowth/differentiation factor 8
- Scientific DescriptionThis gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Kang MJ, Moon JW, Lee JO, et al. Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a. J Cachexia Sarcopenia Muscle. 2022,13(1):605-620. doi: 10.1002/jcsm.12833Read this paper
- Chen MC, Chen YL, Lee CF, et al. Supplementation of Magnolol Attenuates Skeletal Muscle Atrophy in Bladder Cancer-Bearing Mice Undergoing Chemotherapy via Suppression of FoxO3 Activation and Induction of IGF-1. PLoS One. 2015,10(11):e0143594. doi: 10.1371/journal.pone.0143594Read this paper
Datasheet
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