GE2270A [134861-34-0]

AdipoGen Life Sciences

GE2270A

10

134861-34-0

Research Use Only

>95%

C56H55N15O10S6

1290.5

Chemical. CAS: 134861-34-0. Formula: C56H55N15O10S6. MW: 1290.5. Isolated from Planobispora rosea. Thiopeptide antibiotic. Antibacterial agent by inhibiting bacterial protein synthesis. Active against numerous Gram-positive pathogens, including methicillin-resistant strains of Staphylococcus aureus and vancomycin-resistant Enterococcus spp. Inhibitor of domain II of elongation factor Tu (EF-Tu). Inhibits protein synthesis by blocking the GDP to GTP conformational change and by directly competing with aminoacyl-tRNA for the same binding site on EF-Tu. - Thiopeptide antibiotic. Antibacterial agent by inhibiting bacterial protein synthesis. Active against numerous Gram-positive pathogens, including methicillin-resistant strains of Staphylococcus aureus and vancomycin-resistant Enterococcus spp. Inhibitor of domain II of elongation factor Tu (EF-Tu). Inhibits protein synthesis by blocking the GDP to GTP conformational change and by directly competing with aminoacyl-tRNA for the same binding site on EF-Tu.

O=C1C2=CSC(C3=CC=C(C4=NC(C5=N[C@H](C(N6[C@@H](CCC6)C(N)=O)=O)CO5)=CS4)N=C3C7=CSC(C8=CSC(C(NC(CNC(C9=C(COC)SC([C@H](C(C)C)NC(C%10=C(C)SC([C@@](CC(NC)=O)([H])N1)=N%10)=O)=N9)=O)=O)[C@H](C%11=CC=CC=C%11)O)=N8)=N7)=N2

-20°C,2°C to 8°C

12352200